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Recombinant Human TIGIT (C-6His)
Catalog# BDAF0027
Product information
| 产品货号 | BDAF0027 |
| 别名 | T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9 |
| 产品名称 | Recombinant Human TIGIT (C-6His) |
| 类别 | 重组蛋白 |
| 推荐应用 | Dependent by end user |
| 存储缓冲液 | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
| Human Swissprot No. | Q495A1 |
| 参考分子量 | 13-19kDa, reducing conditions |
| 预测分子量 | 13.9kDa |
| 运输及保存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 表达系统 | human cells |
| 内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| 宿主 | human cells |
| 背景介绍 | T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1. |