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Recombinant Rat CD86 (C-6His)
Catalog# BDAF0035
Product information
| 产品货号 | BDAF0035 |
| 别名 | T-lymphocyte activation antigen CD86; Activation B7-2 antigen; CD86 |
| 产品名称 | Recombinant Rat CD86 (C-6His) |
| 类别 | 重组蛋白 |
| 推荐应用 | Dependent by end user |
| 存储缓冲液 | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
| Human Swissprot No. | O35531 |
| 参考分子量 | 35-55kDa, reducing conditions |
| 预测分子量 | 26.7kDa |
| 运输及保存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 表达系统 | human cells |
| 内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| 宿主 | human cells |
| 背景介绍 | T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation. |