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Recombinant Human B7-H3 (C-6His)
Catalog# BDAF0037
Product information
| 产品货号 | BDAF0037 |
| 别名 | CD276; B7H34Ig-B7-H3; B7-H3; B7 homolog 3; CD276 antigen; CD276 molecule; Costimulatory molecule |
| 产品名称 | Recombinant Human B7-H3 (C-6His) |
| 类别 | 重组蛋白 |
| 推荐应用 | Dependent by end user |
| 存储缓冲液 | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
| Human Swissprot No. | Q5ZPR3 |
| 参考分子量 | 65-90kDa, reducing conditions |
| 预测分子量 | 47.5kDa |
| 运输及保存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 表达系统 | human cells |
| 内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| 宿主 | human cells |
| 背景介绍 | CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration. |