发文献得奖励 特价促销,"奖"享不断
Recombinant Human VEGF-C (C-6His)
Catalog# BDAF0048
Product information
| 产品货号 | BDAF0048 |
| 别名 | Vascular Endothelial Growth Factor C; VEGF-C; Flt4 Ligand; Flt4-L; Vascular Endothelial Growth Factor-Related Protein; VRP; VEGFC |
| 产品名称 | Recombinant Human VEGF-C (C-6His) |
| 类别 | 重组蛋白 |
| 推荐应用 | Dependent by end user |
| 存储缓冲液 | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
| Human Swissprot No. | P49767 |
| 参考分子量 | 25-30kDa, reducing conditions |
| 预测分子量 | 100.3kDa |
| 运输及保存条件 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 表达系统 | human cells |
| 内毒素 | Less than 1 EU/µg as determined by LAL test. |
| 宿主 | human cells |
| 背景介绍 | Vascular Endothelial Growth Factor (VEGF)-C is a member of the VEGF family, a group of polypeptide growth factors which play key roles in the physiology and pathology of many aspects of the cardiovascular system, including vasculogenesis, hematopoiesis, angiogenesis and vascular permeability. While VEGFC is homologous to other members of the VEGF/PDGF family, it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF signalling in endothelial cells occurs through three tyrosine kinase receptors (VEGFRs) expressed by endothelial cells and hematopoietic precursors, and VEGF-C is a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. It is indicated that VEGFC undergoes a complex proteolytic maturation generating a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Knockout of the VEGF-C gene is embryonic lethal late in development, and although cells differentiate into the lymphatic lineage, they fail to sprout and form lymphatic vessels. Inactivation of a single VEGF-C allele results in the development of cutaneous lymphatic hypoplasia and lymphedema. |