产品基本信息

• 产品货号 RM9245
• 别名 IGKJRB;IGKJRB1;RBPJK;RBPSUH
• 产品名称 RBPJK (16E2) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 RBPJ
• 蛋白名称 Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)
• Clonality Monoclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 3516
• Human Swissprot No. Q06330
• Mouse Swissprot No. P31266
• 特异性 Endogenous
• 稀释度 WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000
• 参考分子量 61kDa
• 预测分子量 56kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 IgG,Kappa
• 背景介绍 The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013],
• 细胞定位 Nucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.

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