产品基本信息

• 产品货号 RM9255
• 别名 EIF4E;EIF4EL1;EIF4F;Eukaryotic translation initiation factor 4E;eIF-4E;eIF4E;eIF-4F 25 kDa subunit;mRNA cap-binding protein
• 产品名称 eIF4E (Phospho Ser209) (11X14) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 EIF4E
• 蛋白名称 Eukaryotic translation initiation factor 4E
• Clonality Monoclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 1977
• Human Swissprot No. P06730
• Mouse Gene ID 13684
• Mouse Swissprot No. P63073
• Rat Gene ID 117045
• Rat Swissprot No. P63074
• 特异性 eIF4E (Phospho Ser209) Antibody detects endogenous levels of eIF4E protein only when phosphorylated at S209.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the
• 稀释度 WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 25kDa
• 预测分子量 25kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 IgG,Kappa
• 背景介绍 The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
• 细胞定位 Cytoplasm, P-body . Cytoplasm . Cytoplasm, Stress granule . Nucleus . Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257). .

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