产品基本信息

• 产品货号 RM8000
• 别名 Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197)
• 产品名称 Beclin 1 (14P2) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 BECN1 GT197
• 蛋白名称 Beclin-1 (Ser15)
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 8678
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8678
• Human Swissprot No. Q14457
• Human Swissprot Link https://www.uniprot.org/uniprotkb/Q14457/entry
• Mouse Gene ID 56208
• Mouse Gene Link https://www.uniprot.org/uniprot/56208
• Mouse Swissprot No. O88597
• Mouse Swissprot Link https://www.uniprot.org/uniprotkb/O88597
• Rat Gene ID 114558
• Rat Gene Link https://www.uniprot.org/uniprot/114558
• Rat Swissprot No. Q91XJ1
• Rat Swissprot Link https://www.uniprot.org/uniprotkb/Q91XJ1
• 稀释度 IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 60kDa
• 预测分子量 52kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
• 信号通路 Regulation of autophagy;
• 功能 function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,
• 纯化 Protein A

图片

	Western blot analysis of lysates from Hela cells, using Beclin 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.
	Immunohistochemical analysis of paraffin-embedded Mouse kidney tissue. 1, primary Antibody was diluted at 1:200(4℃,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98℃,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).

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