产品基本信息

• 产品货号 BD-PN0090
• 产品名称 2AAA Rabbit Polyclonal Antibody
• 类别 抗体产品
• 基因名称 PPP2R1A
• 蛋白名称 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
• Human Gene ID 5518
• Human Swissprot No. P30153
• Human Swissprot Link https://www.uniprot.org/uniprotkb/P30153/entry
• Mouse Swissprot No. Q76MZ3
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q76MZ3
• 免疫原 Synthesized peptide derived from human protein . at AA range: 500-580
• 特异性 2AAA Polyclonal Antibody detects endogenous levels of protein.
• 稀释度 WB 1:500-2000, ELISA 1:5000-20000
• 预测分子量 64kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010],
• 组织表达 Brain,Cajal-Retzius cell,Colon,Placenta,Testis,
• 细胞定位 Cytoplasm . Nucleus . Chromosome, centromere . Lateral cell membrane . Cell projection, dendrite . Centromeric localization requires the presence of BUB1. .
• 信号通路 Oocyte meiosis;WNT;WNT-T CELLTGF-beta;Tight junction;Long-term depression;
• 功能 domain:Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.,function:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.,similarity:Belongs to the phosphatase 2A regulatory subunit A family.,similarity:Contains 15 HEAT repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

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