产品基本信息

• 产品货号 BD-PN1858
• 别名 ANPRA
• 产品名称 ANPRA Rabbit Polyclonal Antibody
• 类别 抗体产品
• 基因名称 NPR1
• 蛋白名称 Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
• Human Gene ID 4881
• Human Swissprot No. P16066
• Human Swissprot Link https://www.uniprot.org/uniprotkb/P16066/entry
• Mouse Swissprot No. P18293
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P18293
• Rat Swissprot No. P18910
• Rat Swissprot Link http://www.uniprot.org/uniprot/O54941P18910
• 免疫原 Synthesized peptide derived from part region of human protein
• 特异性 ANPRA Polyclonal Antibody detects endogenous levels of protein.
• 稀释度 WB 1:500-2000, ELISA 1:5000-20000
• 预测分子量 116kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (A
• 组织表达 Blood,Kidney,Placenta,Retina,
• 细胞定位 Membrane; Single-pass type I membrane protein.
• 信号通路 Purine metabolism;Vascular smooth muscle contraction;
• 功能 catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,function:Receptor for atrial natriuretic peptide. Has guanylate cyclase activity on binding of ANF.,miscellaneous:There seem to be at least three natriuretic peptide hormone receptors: two with guanylate cyclase activity (NPR1/ANP-A and NPR2/ANP-B) and one (NPR3/ANP-C) which is probably responsible for the clearance of natriuretic peptides from the circulation without a role in signal transduction.,PTM:Phosphorylation of the protein kinase-like domain is required for full activation by ANP.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,similarity:Contains 1 protein kinase domain.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

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