产品基本信息

• 产品货号 RM8091
• 别名 CD36;GP3B;GP4;Platelet glycoprotein 4;Fatty acid translocase;FAT;Glycoprotein IIIb;GPIIIB;Leukocyte differentiation antigen CD36;PAS IV;PAS-4;Platelet collagen receptor;Platelet glycoprotein IV;GPIV;Thrombospondin receptor;CD36
• 产品名称 CD36 (13O1) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 CD36
• 蛋白名称 Platelet glycoprotein 4
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 948
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948
• Human Swissprot No. P16671
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P16671/entry
• Mouse Gene ID 12491
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12491
• Mouse Swissprot No. Q08857
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q08857
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
• Rat Swissprot No. Q07969
• Rat Swissprot Link http://www.uniprot.org/uniprot/Q07969
• 稀释度 IHC-P 1:1000-1:4000, WB 1:1000-1:5000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000
• 参考分子量 90kDa
• 预测分子量 53kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014],
• 信号通路 PPAR;ECM-receptor interaction;Hematopoietic cell lineage;Adipocytokine;
• 功能 disease:Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.,disease:Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].,function:Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.,online information:CD36 entry,polymorphism:Genetic variation in CD36 influences the severity and outcome of malaria infection.,PTM:N-glycosylated and O-glycosylated with a ratio of 2:1.,similarity:Belongs to the CD36 family.,
• 纯化 Protein A

图片

Western blot analysis of lysates from Mouse spleen cells, using CD36 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.

产品详情