产品基本信息

• 产品货号 RM8282
• 别名 HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;HSP 90;Heat shock 84 kDa;HSP 84;HSP84
• 产品名称 Hsp90 (11O6) Rabbit Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 HSP90AB1
• 蛋白名称 Heat shock protein HSP 90-beta
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 3326
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3326
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P08238/entry
• Mouse Gene ID 15516
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15516
• Mouse Swissprot No. P11499
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P11499
• Rat Gene ID 301252
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=301252
• Rat Swissprot No. P34058
• Rat Swissprot Link http://www.uniprot.org/uniprot/P34058
• 稀释度 IHC-P 1:200-1000,WB 1:1000-5000,IF-P/IF-F/IF-ICC 1:200-1000,ELISA 1:5000-20000,IP 1:50-200
• 参考分子量 85kDa
• 预测分子量 85kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],
• 信号通路 PI3K/Akt; Protein_Acetylation
• 功能 function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,
• 纯化 Protein A

图片

	Western blot analysis of lysates from PC12 cells, using Hsp90 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.
	Immunohistochemical analysis of paraffin-embedded Human testis tissue. 1, primary Antibody was diluted at 1:200(4℃,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98℃,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).

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