产品基本信息

• 产品货号 BD-PT1089
• 别名 CPN1; ACBP; Carboxypeptidase N catalytic chain; CPN; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; S
• 产品名称 CPN cat Rabbit Polyclonal Antibody
• 类别 抗体产品
• 基因名称 CPN1
• 蛋白名称 Carboxypeptidase N catalytic chain
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Rat,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 1369
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1369
• Human Swissprot No. P15169
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P15169/entry
• Mouse Swissprot No. Q9JJN5
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q9JJN5
• 免疫原 The antiserum was produced against synthesized peptide derived from human CPN1. AA range:409-458
• 特异性 CPN cat Polyclonal Antibody detects endogenous levels of CPN cat protein.
• 稀释度 WB 1:500-1:2000, ELISA 1:20000.Not yet tested in other applications.
• 预测分子量 total 52kDa,Cleaved 48kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008],
• 组织表达 Synthesized in the liver and secreted in plasma.
• 细胞定位 Secreted, extracellular space.
• 功能 catalytic activity:Release of a C-terminal basic amino acid, preferentially lysine.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in CPN1 are the cause of carboxypeptidase N deficiency [MIM:212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.,function:Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.,similarity:Belongs to the peptidase M14 family.,subunit:Tetramer of two catalytic chains and two glycosylated inactive chains.,tissue specificity:Synthesized in the liver and secreted in plasma.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Western blot analysis of lysates from RAW264.7 cells, using CPN1 Antibody. The lane on the right is blocked with the synthesized peptide.
	Western Blot analysis of various cells using CPN cat Polyclonal Antibody
	Western Blot analysis of Hela cells using CPN cat Polyclonal Antibody

产品详情