产品基本信息

• 产品货号 RM7429
• Uniprot ID P19544, P22561, P49952
• Gene ID 7490, 22431, 24883
• 别名 GUD; AWT1; WAGR; WT-1; WT33; NPHS4; WIT-2
• 产品名称 WT1 (3J13) Rabbit Monoclonal Antibody
• 类别 抗体产品
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-ICC
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% New type preservative N and 0.05% BSA.
• 免疫原 Recombinant protein of human WT1
• 稀释度 WB 1:1000, IHC-P/IF-P 1:200-1:500, IF-ICC 1:50
• 参考分子量 51-60kDa
• 预测分子量 49kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 IgG
• 背景介绍 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
• 纯化 Affinity Purification

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产品详情