产品基本信息

• 产品货号 RM7457
• Uniprot ID Q92466
• Gene ID 1643
• 别名 XPE; DDBB; UV-DDB2
• 产品名称 DDB2 (19B2) Rabbit Monoclonal Antibody
• 类别 抗体产品
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P
• 反应种属 Human
• 存储缓冲液 Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% New type preservative N and 0.05% BSA.
• 免疫原 A synthetic peptide of human DDB2
• 稀释度 WB 1:1000-1:5000 , IHC-P/IF-P 1:500-1:2000
• 参考分子量 48kDa
• 预测分子量 48kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 IgG
• 背景介绍 This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
• 纯化 Affinity Purification

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产品详情