产品基本信息

• 产品货号 RM7491
• Uniprot ID P29274, Q60613, P30543
• Gene ID 135, 11540, 25369
• 别名 A2aR; RDC8; ADORA2
• 产品名称 Adenosine receptor A2a (10T17) Rabbit Monoclonal Antibody
• 类别 抗体产品
• Clonality Monoclonal
• 推荐应用 IHC-P,IF-P
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% New type preservative N and 0.05% BSA.
• 免疫原 A synthetic peptide of human Adenosine receptor A2a
• 稀释度 IHC-P/IF-P 1:100
• 预测分子量 45kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 IgG
• 背景介绍 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
• 纯化 Affinity Purification

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产品详情