产品基本信息

• 产品货号 RM9417
• 别名 GRK1;RHOK;Rhodopsin kinase;RK;G protein-coupled receptor kinase 1
• 产品名称 GRK1 (18W3) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 GRK1
• 蛋白名称 Rhodopsin kinase
• Clonality Monoclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 6011
• Human Swissprot No. Q15835
• Mouse Swissprot No. Q9WVL4
• Rat Gene ID 81760
• Rat Swissprot No. Q63651
• 特异性 Endogenous
• 稀释度 WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;
• 参考分子量 64kDa
• 预测分子量 64kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 IgG,Kappa
• 背景介绍 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008],
• 组织表达 Retinal-specific. Expressed in rods and cones cells.
• 细胞定位 Membrane ; Lipid-anchor . Cell projection, cilium, photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. .
• 功能 Catalytic activity:ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.,Disease:Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.,Function:Phosphorylates rhodopsin thereby initiating its deactivation.,online information:Retina International's Scientific Newsletter,PTM:Autophosphorylated.,PTM:Farnesylation is required for full activity.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Retina and pineal gland.,

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