产品基本信息

• 产品货号 RM9425
• 别名 DUSP9;MKP4;Dual specificity protein phosphatase 9;Mitogen-activated protein kinase phosphatase 4;MAP kinase phosphatase 4;MKP-4
• 产品名称 MKP-4 (3S3) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 DUSP9
• 蛋白名称 Dual specificity protein phosphatase 9
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 1852
• Human Swissprot No. Q99956
• 特异性 Endogenous
• 稀释度 IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;
• 参考分子量 42kDa
• 预测分子量 42kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 IgG,Kappa
• 背景介绍 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progr
• 组织表达 Kidney,Liver,Lung,Placenta,
• 细胞定位 Cytoplasm.
• 功能 Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Inactivates MAP kinases. Has a specificity for the ERK family.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

图片

	Immunohistochemical analysis of paraffin-embedded Human kidney
	Immunohistochemical analysis of paraffin-embedded Human testis

产品详情