产品基本信息

• 产品货号 RM9430
• 别名 F3;Tissue factor;TF;Coagulation factor III;Thromboplastin;CD142
• 产品名称 TF (9B10) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 F3
• 蛋白名称 Tissue factor
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 2152
• Human Swissprot No. P13726
• Mouse Swissprot No. P20352
• 特异性 Endogenous
• 稀释度 IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;
• 参考分子量 50kDa
• 预测分子量 33kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 IgG,Kappa
• 背景介绍 This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
• 组织表达 Lung, placenta and pancreas.
• 细胞定位 [Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
• 功能 Function:Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.,induction:TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.,online information:The Singapore human mutation and polymorphism database,online information:Tissue factor entry,similarity:Belongs to the tissue factor family.,

图片

Immunohistochemical analysis of paraffin-embedded Human kidney

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