产品基本信息

• 产品货号 RM9783
• 产品名称 TIA1 (7C4) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 TIA1
• 蛋白名称 Nucleolysin TIA-1 isoform p40 (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1)
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 7072
• Human Swissprot No. P31483
• Mouse Swissprot No. P52912
• 特异性 Endogenous
• 稀释度 IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200
• 参考分子量 42,44kDa
• 预测分子量 43kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 IgG,Kappa
• 背景介绍 The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq , Jul 2008] ,
• 细胞定位 Nucleus . Cytoplasm . Cytoplasm , Stress granule . Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:15371533 , PubMed:10613902) . Recruitment to SG is induced by Zn (2+) (By similarity) . .
• 纯化 Recombinant Antibody  expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.

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