产品基本信息

• 产品货号 BD-PT5034
• 别名 GDI1; GDIL; OPHN2; RABGDIA; XAP4; Rab GDP dissociation inhibitor alpha; Rab GDI alpha; Guanosine diphosphate dissociation inhibitor 1; GDI-1; Oligophrenin-2; Protein XAP-4
• 产品名称 GDI-1 Rabbit Polyclonal Antibody
• 类别 抗体产品
• 基因名称 GDI1
• 蛋白名称 Rab GDP dissociation inhibitor alpha
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 2664
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2664
• Human Swissprot No. P31150
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P31150/entry
• Mouse Gene ID 14567
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14567
• Mouse Swissprot No. P50396
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P50396
• Rat Gene ID 25183
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25183
• Rat Swissprot No. P50398
• Rat Swissprot Link http://www.uniprot.org/uniprot/P50398
• 免疫原 The antiserum was produced against synthesized peptide derived from human GDI-1. AA range:394-443
• 特异性 GDI-1 Polyclonal Antibody detects endogenous levels of GDI-1 protein.
• 稀释度 WB 1:500-1:2000, ELISA 1:20000.Not yet tested in other applications.
• 预测分子量 50kDa
• 运输及保存条件 Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008],
• 组织表达 Brain; predominant in neural and sensory tissues.
• 细胞定位 Cytoplasm . Golgi apparatus, trans-Golgi network .
• 功能 disease:Defects in GDI1 are the cause of mental retardation X-linked type 41 (MRX41) [MIM:300104]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,disease:Defects in GDI1 are the cause of mental retardation X-linked type 48 (MRX48) [MIM:300104]; also known as MRX3.,function:Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rab GDI family.,tissue specificity:Brain; predominant in neural and sensory tissues.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Western blot analysis of lysates from brain tissue, using GDI-1 antibody.
	Western Blot analysis of extracts from K562 cells, using GDI-1 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

产品详情