产品基本信息

• 产品货号 BD-PT5909
• 别名 Follitropin subunit beta (Follicle-stimulating hormone beta subunit;FSH-B;FSH-beta;Follitropin beta chain)
• 产品名称 FSHβ Rabbit Polyclonal Antibody
• 类别 抗体产品
• 基因名称 FSHB
• 蛋白名称 Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain)
• Clonality Polyclonal
• 推荐应用 IHC-P,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 2488
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2488
• Human Swissprot No. P01225
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P01225/entry
• Mouse Gene ID 14308
• Mouse Swissprot No. Q60687
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q60687
• Rat Swissprot No. P18427
• Rat Swissprot Link http://www.uniprot.org/uniprot/O54941P18427
• 免疫原 Synthetic peptide from human protein at AA range: 10-50
• 特异性 The antibody detects endogenous FSHβ
• 稀释度 IHC-P 1:50-200, ELISA 1:10000-20000, IF-P/IF-F/IF-ICC 1:50-200
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 follicle stimulating hormone beta subunit(FSHB) Homo sapiens The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
• 细胞定位 Secreted . Efficient secretion requires dimerization with CGA. .
• 信号通路 Neuroactive ligand-receptor interaction;GnRH;
• 功能 disease:Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men.,function:Stimulates development of follicle and spermatogenesis in the reproductive organs.,online information:Follicle-stimulating hormone entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis.,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200

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