产品基本信息
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产品货号
BD-PA2162
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别名
INHA; inhibin, alpha
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产品名称
INHA (Inhibin alpha)（4A2） Mouse Monoclonal Antibody
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类别
抗体产品
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Clonality
Monoclonal
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推荐应用
IHC-P,ICC,ELISA
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反应种属
Human
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存储缓冲液
Ascitic fluid containing 0.03% New type preservative N.
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Human Gene ID
3623
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免疫原
Purified recombinant fragment of human INHA expressed in E. Coli.
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稀释度
IHC-P 1:200-1:1000, ICC 1:200-1:1000, ELISA 1:10000
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预测分子量
40kDa
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运输及保存条件
Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
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宿主
Mouse
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同种型
IgG1
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克隆号
4A2
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纯度
crude ascites
图片
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Confocal Immunofluorescence analysis of Hela cells using INHA mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. |
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Immunohistochemical analysis of paraffin-embedded human lymphoid (A), ovary tumor (B) and testicle tumor (C) tissues using INHA mouse mAb with DAB staining. |
产品详情
INHA (A-inhibin subunit precursor, inhibin alpha subunit ), also called inhibin (alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.
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